周智曌;张峰;

• 1:咸阳市杨凌示范区医院新生儿科

摘要(Abstract)：

目的评估抗菌药物对羊水胎粪污染后新生儿脓毒症发展的预防作用。方法选择2013年10月至2015年10月符合条件的新生儿250例,随机分为研究组(抗菌药物组,125例,一线抗菌药物治疗3 d)和对照组(无抗菌药物组,125例)。评估两组脓毒症的发病率,监测所有新生儿的呼吸系统、神经系统和全身并发症。结果研究组和对照组脓毒症的发病率比较差异无统计学意义(4.17%vs.5.42%,P=0.63,OR=0.86,95%CI=0.32¹.73)。两组呼吸窘迫的严重程度和持续时间、胎粪吸入综合征的严重程度和发病率、氧疗或机械通气的需求和持续时间以及两组并发症(持续性肺动脉高压、颅内出血、腹泻、死亡、缺血缺氧性脑病等)发生率比较差异无统计学意义(P>0.05)。结论常规抗菌药物预防不会降低羊水胎粪污染的新生儿脓毒症的发病率。因此,在婴儿没有确诊感染的前提下,建议避免滥用抗菌药物。

关键词(KeyWords)： 预防;抗菌药物;新生儿脓毒症;羊水胎粪污染

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 周智曌;张峰;

DOI: 10.14053/j.cnki.ppcr.201608020

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