卡培他滨联合螺旋断层放疗治疗术后复发及局部晚期直肠癌的护理
吕东阳;
摘要(Abstract):
目的总结卡培他滨同期化疗联合螺旋断层放疗治疗复发和局部晚期直肠癌的临床护理措施。方法对31例复发和局部晚期直肠癌患者卡培他滨化疗同期联合螺旋断层放疗的临床资料进行回顾性分析。结果本组31例患者中CR 5例,PR 20例,总有效率为80.65%。主要不良反应为手足综合征、骨髓抑制、恶心呕吐、放射性直肠炎及膀胱炎等,均无Ⅲ度~Ⅳ度毒副反应。本组患者治疗过程均顺利,没有因不良反应延长治疗时间,无不良反应相关死亡。结论卡培他滨同期螺旋断层放疗治疗复发和局部晚期直肠癌配合有效的护理措施,能有效减轻放化疗的不良反应,缓解临床症状,提高患者的生活质量,有利于患者的预后和康复。
关键词(KeyWords): 卡培他滨;螺旋断层;放射治疗;直肠癌
基金项目(Foundation):
作者(Authors): 吕东阳;
DOI: 10.14053/j.cnki.ppcr.2012.11.009
参考文献(References):
- [1]张伟东,苗树军.我国恶性肿瘤死亡率流行病学特征分析[J].中国健康教育,2009,25(4):246-248.
- [2]Davies ML,Harris D,Davies M,et al.Selection Criteria for theRadical Treatment of Locally Advanced Rectal Cancer[J].Int JSurg Oncol,2011,2011:678506.
- [3]Díaz-Rubio E,Evans TR,Tabemero J,et al.Capecitabine(Xe-loda)in combination with oxaliplatin:a phase I,dose-escalationstudy in patients with advanced or metastatic solid tumors[J].Ann Oncol,2002,13(4):558-565.
- [4]Van Cutsem E,Twelves C,Cassidy J,et al.Oral capecitabineeompared with intravenous fluorouracil plus leueovorin in pa-tients withmetastatic colorectal cancer:results of a large phaseIII study[J].J Clin Oncol,2001,19(21):4097-4106.
- [5]Cassidy J,Clarke S,Dlaz-Rubio E,et al.Randomized phase IIIstudy of eapeeitabine plus oxaliplatin compared with fluoroura-cil/folinic acid plus oxaliplatin as first-line therapy for metastat-ic colorectal cancer[J].J Clin Oncol,2008,26(12):2006-2012.
- [6]Machiels JP,Duck L,Honhon B,et al,Phase II study of preop-erative oxaliplatin,capecitabine and external beam radiotherapyin patients with rectal cancer:the RadiOxCape study[J].An-nals of Oncology,2005,16(2):1898-1905.
- [7]Krishnan S,Janjan NA,Skibber JM,et al.Phase II study ofcapecitabine(Xeloda)and concomitant boost radiotherapy inpatients with locally advanced rectal cancer[J].Int J RadiatOncol Biol Phys,2006,66(3):762-771.
- [8]Fuchs CS,Marshall J,Mitchell E,et al.Randomized,controlledtrial of irinotecan plus infusional,bolus,or oral fluoropyrimi-dines in first-line treatment of metastatic coloreetal cancer:re-sults from the BICC-C Study[J].J Clin Oncol,2007,25(30):4779-4786.
- [9]Heo YS,Chang HM,Kim TW,et al.Hand-foot syndrome inpatients treated with capecitabine-containing combination chem-otherapy[J].J Clin Pharmacol,2004,44(10):1166-1172.